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. 1982 Mar;43(3):503-8.
doi: 10.1128/aem.43.3.503-508.1982.

Metabolism of verruculogen in rats

K P Perera, J B Day, P G Mantle, L Rodrigues

Metabolism of verruculogen in rats

K P Perera et al. Appl Environ Microbiol. 1982 Mar.

Abstract

Radiolabeled verruculogen was detected in a wide range of body tissues 6 min after intravenous administration, but after a further 20 min it was mainly being excreted via the biliary route. In isolated liver perfusion, [14C]verruculogen was rapidly taken up by the liver and metabolized completely, principally to the related tremorgen TR-2 but also to a desoxy derivative of verruculogen. In addition, a smaller amount of an isomer of TR-2 was detected. These metabolic products were excreted in the bile.

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