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. 1982 Mar;43(3):514-6.
doi: 10.1128/aem.43.3.514-516.1982.

Biosynthesis of radiolabeled verruculogen by Penicillium simplicissimum

J B Day, P G Mantle

Biosynthesis of radiolabeled verruculogen by Penicillium simplicissimum

J B Day et al. Appl Environ Microbiol. 1982 Mar.

Abstract

In surface culture of Penicillium simplicissimum, verruculogen was shown to be biosynthesized from the intact carbon skeletons of tryptophan and proline, isoprenoid derivatives of mevalonic acid, and a methyl group donated by methionine. Selected radiolabeled precursors (1 mCi) pulse-fed at the optimum stage of fermentation yielded verruculogen (specific activity, 5.89 X 10(2) microCi mmol-1) labeled in the prolyl and isoprenyl regions of the molecule and suitable for metabolic studies.

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