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Clinical Trial
. 1982 May;45(5):655-69.
doi: 10.1038/bjc.1982.106.

The cancer research campaign (King's/Cambridge trial for early breast cancer: clinico-pathological aspects

C W Elston, G A Gresham, G S Rao, T Zebro, J L Haybittle, J Houghton, G Kearney
Free PMC article
Clinical Trial

The cancer research campaign (King's/Cambridge trial for early breast cancer: clinico-pathological aspects

C W Elston et al. Br J Cancer. 1982 May.
Free PMC article

Abstract

Analysis of pathological data in the 10th year of follow-up of a multicentre trial of the management of operable breast cancer has confirmed the correlation of prognosis with tumour grade, tumour size and lymph-node status. For each factor examined there was no difference in survival between the 2 treatment groups ("watch policy" and radiotherapy) but patients in the WP group whose tumours were of Grade II or III or greater than 2 cm, or with lymph-node metastases, had a greater chance of local recurrence. Cellular reaction had no relationship with prognosis, except in patients with Grade III tumours. The clinical relevance and application of these results are discussed.

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