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. 1982;185(2):352-5.
doi: 10.1007/BF00330811.

Damage to DNA induces expression of the ruv gene of Escherichia coli

C E Shurvinton, R G Lloyd

Damage to DNA induces expression of the ruv gene of Escherichia coli

C E Shurvinton et al. Mol Gen Genet. 1982.

Abstract

Regulation of the ruv gene of E. coli was studied using phage Mud (Ap lac) to obtain a fusion of the lac genes to the ruv promoter. Beta-galactosidase synthesis in the ruv-lac fusion strain was induced by mitomycin C and other agents that damage DNA. The induction of beta-galactosidase could be altered by mutations either in lexA or recA from which it is concluded that ruv is regulated by lexA repressor. A possible function of ruv in promoting cell recovery following damage to DNA is discussed.

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References

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