Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1982 Jul 22;298(5872):347-50.
doi: 10.1038/298347a0.

Synthesis and assembly of hepatitis B virus surface antigen particles in yeast

P Valenzuela, A Medina, W J Rutter, G Ammerer, B D Hall

Synthesis and assembly of hepatitis B virus surface antigen particles in yeast

P Valenzuela et al. Nature. .

Abstract

The surface antigens of hepatitis B virus (HBsAg) has been synthesized in the yeast Saccharomyces cerevisiae by using an expression vector that employs the 5'-flanking region of yeast alcohol dehydrogenase I as a promotor to transcribe surface antigen coding sequences. The protein synthesized in yeast is assembled into particles having properties similar to the 22-nm particles secreted by human cells.

PubMed Disclaimer

Publication types

Associated data

LinkOut - more resources