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. 1982 Apr 26;29(3):281-6.
doi: 10.1016/0304-3940(82)90330-5.

Effects of optical isomers of ketamine on excitation of cat and rat spinal neurones by amino acids and acetylcholine

D Lodge, N A Anis, N R Burton

Effects of optical isomers of ketamine on excitation of cat and rat spinal neurones by amino acids and acetylcholine

D Lodge et al. Neurosci Lett. .

Abstract

The (+) isomer of ketamine was approximately 3 and 1.5 times as potent as the (-) isomer in reducing excitation of rat and cat Renshaw cells by N-methylaspartate (NMA) and acetylcholine (ACh) respectively. The potency ratio of the two isomers of ketamine as NMA antagonists was similar to that obtained in anaesthetic and analgesic tests [16, 19, 25].

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