doi: 10.1016/0090-6980(78)90149-1.
Prostaglandins restore the hyoscine-induced inhibition of the guinea-pig ileum
- PMID: 704907
- DOI: 10.1016/0090-6980(78)90149-1
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Prostaglandins restore the hyoscine-induced inhibition of the guinea-pig ileum
Prostaglandins.
1978 May.
Abstract
Prostaglandins E1, E2 and F2alpha as well as arachidonic acid partially increase the hyoscine inhibited twitch and tetanic responses of the guinea-pig ileum to electrical stimulation. They also produce a shift to the left of the dose-effect curve for acetylcholine and histamine previously displaced to the right by the administration of hyoscine or mepyramine. These results indicate a postsynaptic sensitization effect of the prostaglandins rather than a presynaptic facilitatory activity.
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