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. 1978 May;15(5):829-37.
doi: 10.1016/0090-6980(78)90149-1.

Prostaglandins restore the hyoscine-induced inhibition of the guinea-pig ileum

G M Laekeman, A G Herman

Prostaglandins restore the hyoscine-induced inhibition of the guinea-pig ileum

G M Laekeman et al. Prostaglandins. 1978 May.

Abstract

Prostaglandins E1, E2 and F2alpha as well as arachidonic acid partially increase the hyoscine inhibited twitch and tetanic responses of the guinea-pig ileum to electrical stimulation. They also produce a shift to the left of the dose-effect curve for acetylcholine and histamine previously displaced to the right by the administration of hyoscine or mepyramine. These results indicate a postsynaptic sensitization effect of the prostaglandins rather than a presynaptic facilitatory activity.

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