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. 1982 Jun 25;10(12):3703-13.
doi: 10.1093/nar/10.12.3703.

The complete sequence and coding content of snowshoe hare bunyavirus small (S) viral RNA species

D H Bishop, K G Gould, H Akashi, C M Clerx-van Haaster
Free PMC article

The complete sequence and coding content of snowshoe hare bunyavirus small (S) viral RNA species

D H Bishop et al. Nucleic Acids Res. .
Free PMC article

Abstract

The complete sequence of the small (S) viral RNA species of snowshoe hare (SSH) bunyavirus has been determined, principally from a DNA copy of the RNA cloned in the E.coli plasmid pBr322. The viral S RNA (negative sense strand) is 982 nucleotides long (3.3 x 10(5) daltons) with complementary 5' and 3' end sequences. It has a base composition of 30.5%U, 25.8%A, 24.9%C and 18.7%G. In the viral complementary (plus sense) strand there are two overlapping open reading frames initiated by methionine codons. One reading frame codes for a 26.8 x 10(3) dalton protein, the other for a 10.5 x 10(3) dalton protein. The larger gene product is presumably related to the viral nucleoprotein (N) that is coded by the S RNA (Gentsch and Bishop (1978) J. Virol. 28, 417-419). The smaller gene product is probably related to the recently identified S RNA coded nonstructural protein (NSS) induced in virus infected cells (Fuller and Bishop (1982) J. Virol. 41, 643-648).

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References

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