Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1980 Mar;68(3):541-9.
doi: 10.1111/j.1476-5381.1980.tb14570.x.

The binding of some antidepressant drugs to brain muscarinic acetylcholine receptors

P R Golds, F R Przyslo, P G Strange

The binding of some antidepressant drugs to brain muscarinic acetylcholine receptors

P R Golds et al. Br J Pharmacol. 1980 Mar.

Abstract

1 The binding of some antidepressant drugs, including some new drugs of atypical structure (flupenthixol, iprindole, maprotiline, mianserin, nomifensine, tofenacine and viloxazine) to muscarinic acetylcholine receptors in the brain has been studied by displacement of [3H]-atropine. 2 Many of the drugs are potent muscarinic antagonists. 3 Some correlation can be made between the affinity for binding to the muscarinic acetylcholine receptor and the incidence of anticholinergic side effects in clinical usage.

PubMed Disclaimer

References

    1. Br J Psychiatry. 1967 Sep;113(502):999-1004 - PubMed
    1. J Biol Chem. 1951 Nov;193(1):265-75 - PubMed
    1. Eur J Pharmacol. 1969 Mar;5(4):367-73 - PubMed
    1. Biochem Pharmacol. 1971 Jan;20(1):103-17 - PubMed
    1. Nature. 1974 Apr 12;248(449):596-7 - PubMed