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. 1980 Oct 20;20(1):67-71.
doi: 10.1016/0304-3940(80)90235-9.

Changes in rat hypothalamic and brain stem catecholamine concentrations following acute administration of phenylethanolamine-N-methyltransferase inhibitors

I N Mefford, K A Roth, J D Barchas

Changes in rat hypothalamic and brain stem catecholamine concentrations following acute administration of phenylethanolamine-N-methyltransferase inhibitors

I N Mefford et al. Neurosci Lett. .

Abstract

The effect of acute phenylethanolamine-N-methyltransferase (PNMT) inhibition on rat brain catecholamine concentrations was studied. All PNMT inhibitors tested were effective in depleting hypothalamic and brain stem epinephrine. Norepinephrine concentrations were unaffected; however, dopamine levels were increased in all areas studied. While several possible explanations are offered for this phenomenon, the mechanism is not yet understood.

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