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. 1982 Jan;66(1):121-5.

Doxorubicin cytotoxicity enhanced by local anesthetics in a human melanoma cell line

R T Chlebowski, J B Block, D Cundiff, M F Dietrich
  • PMID: 7053248

Doxorubicin cytotoxicity enhanced by local anesthetics in a human melanoma cell line

R T Chlebowski et al. Cancer Treat Rep. 1982 Jan.

Abstract

Local anesthetics may influence cell membrane structure and permeability. An established human melanoma cell line (SHG) derived from malignant ascites was used to evaluate the growth-inhibitory effects of local anesthetics (procaine and lidocaine) as well as of doxorubicin at incubation temperatures of 37.5 degrees C and 40 degrees C. In this system, procaine and lidocaine inhibited growth at 0.82 mg/ml and doxorubicin inhibited growth at 28 ng/ml. Noninhibitory concentrations of procaine (0.64 mg/ml) when combined with noninhibitory concentrations of doxorubicin (10 ng/ml) resulted in marked growth inhibition. Incubating temperatures of 40 degrees C enhanced all effects of procaine and doxorubicin on cell growth. These results suggest that clinically achievable concentrations of local anesthetics enhance doxorubicin cytotoxicity.

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