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. 1982 Jan;66(1):173-5.

Phase I trial of spirogermanium given by infusion in a multiple-dose schedule

D R Budman, P Schulman, V Vinciguerra, T J Degnan
  • PMID: 7053254

Phase I trial of spirogermanium given by infusion in a multiple-dose schedule

D R Budman et al. Cancer Treat Rep. 1982 Jan.

Abstract

In a phase I study of spirogermanium, a new azaspiran-germanium compound, 28 patients were given a multiple-dose schedule. When infused over 1 hour, the maximum tolerated single dose of this agent was greater than 120 mg/m2 but significant chronic neurologic toxicity occurred after 1-2 weeks of treatment. Patients with a poor performance status (PS) were the most likely to manifest toxic reactions. Suggested phage II dose levels for infusion treatment with spirogermanium are 120 mg/m2 for patients with a PS of 0-2 and 80 mg/m2 for patients with a PS of 3.

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