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. 1978 Aug;12(2):109-14.
doi: 10.1111/j.1399-0039.1978.tb01306.x.

HLA and thyrotoxicosis (Graves' disease) in Chinese

S H Chan, P P Yeo, K F Lui, G B Wee, K T Woo, P Lim, J S Cheah

HLA and thyrotoxicosis (Graves' disease) in Chinese

S H Chan et al. Tissue Antigens. 1978 Aug.

Abstract

HLA locus A and B typing was performed on 86 Chinese thyrotoxicosis (Graves' Disease) patients and 238 normal Chinese subjects. The frequency of HLA-Bw46 (Sin 2) was found to be significantly higher among the patients than controls (x2 = 26.15, corrected P less than .003, relative risk = 3.74). The risk associated with Bw46 was reflected in the Bw46 heterozygotes. The relative risks of the joint occurrence of Bw46/B40 and Bw46/B13 were 8.74 and 5.88 respectively.

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