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. 1982 Jan;16(1):181-3.
doi: 10.1016/0091-3057(82)90033-8.

Parameters of low-dose ethanol intravenous self-administration in the rat

J D Sinden, J Le Magnen

Parameters of low-dose ethanol intravenous self-administration in the rat

J D Sinden et al. Pharmacol Biochem Behav. 1982 Jan.

Abstract

Male Wistar rats were able to press on an operant lever 24 hr/day for intravenous infusions of saline or ethanol at doses of 0.5, 1.0 or 5.0 mg/kg/infusion. Only the 1.0 mg/kg/infusion group showed a significant increase in responding on the lever as a function of days, whereas the 5.0 mg/kg/infusion group showed a significant decrease in responding as a function of days. The results suggest that the reinforcing value of intravenous ethanol changes from rewarding to neutral or aversive in valence at dose-level below that expected to produce signs of intoxication.

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