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. 1982;102(3):271-5.
doi: 10.1007/BF00411347.

Tumor promoter-stimulated synthesis of Mason-:Pfizer monkey virus

V Wunderlich, L Baumbach, G Sydow

Tumor promoter-stimulated synthesis of Mason-:Pfizer monkey virus

V Wunderlich et al. J Cancer Res Clin Oncol. 1982.

Abstract

The tumor promoter 12-0-tetradecanoyl-phorbol-14-acetate (TPA) increases by severalfold the synthesis of Mason-Pfizer monkey virus (MPMV), a type D retrovirus, when the virus is growing in human embryo kidney (HEK) cells. The effect is transient and paralleled by a striking morphological alteration of the cells. The optimal TPA concentration for stimulation is 5 ng. ml-1. Contrary to infected HEK cells, TPA induces at similar concentrations neither stimulation of MPMV synthesis nor altered morphology in persistently MPMV-infected cells of the continuous human tumor cell line A 204.

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