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. 1982 Apr;30(4):395-7.
doi: 10.1177/30.4.7061831.

Cleavage and cross-linking of proteins with osmium (VII) reagents

M Emerman, E J Behrman

Cleavage and cross-linking of proteins with osmium (VII) reagents

M Emerman et al. J Histochem Cytochem. 1982 Apr.

Abstract

The specific cleavage of proteins following reaction with osmium tetroxide is slowed down by tertiary amines which are known to be good ligands for osmium. Bidentate ligands are more effective than monodentate ligands. These same ligands also promote an intermolecular cross-linking reaction.

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