doi: 10.1111/j.1471-4159.1982.tb05356.x.
Uptake and calcium-dependent release of ethylenediamine (1,2-diaminoethane) by rat brain slices
- PMID: 7062034
- DOI: 10.1111/j.1471-4159.1982.tb05356.x
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Uptake and calcium-dependent release of ethylenediamine (1,2-diaminoethane) by rat brain slices
J Neurochem.
1982 Apr.
Abstract
The uptake of [14C]ethylenediamine into slices of rat brain and its subsequent evoked release have been studied. An active uptake process was demonstrated by comparing uptake at 37 and 4 degrees C. This uptake showed a Km of 1.36 mM, was partly sodium-dependent and was reduced by nipecotic acid. Release could be readily evoked by 30 mM potassium, and by electrical stimulation, the release in both cases being calcium-dependent. In view of these findings and the reported interactions of ethylenediamine with gamma-aminobutyric acid-related mechanisms, it might be of interest to determine whether this simple diamine occurs endogenously in the mammalian brain.
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