[Significance of modifying factors in the development of peripheral nervous system tumors in rabbits]

Abstract

The experiments conducted on 170 rabbits have indicated that the development of neurogenic tumors under the exposure to methylnitrosourea procedes more rapidly in immunization with the tissue homogenate from the rabbit sciatic nerve (using a complete Freund's adjuvant) in chronic irritation of the peripheral trunk and in hypothyroidism and estrogenization of the organism of animals under test. Castration and thyroidin administration would reduce the number of experimental tumors of the peripheral nervous system and lengthen the latent period of their development.