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. 1982 Apr 9;216(4542):196-8.
doi: 10.1126/science.7063880.

Bronchoconstrictor effects of leukotriene C in humans

J W Weiss, J M Drazen, N Coles, E R McFadden Jr, P F Weller, E J Corey, R A Lewis, K F Austen

Bronchoconstrictor effects of leukotriene C in humans

J W Weiss et al. Science. .

Abstract

Maximum expiratory flow rate at 30 percent of vital capacity above residual volume served as an index of airway obstruction in comparing the effects of leukotriene C and histamine administered by aerosol to five normal persons. Leukotriene C was 600 to 9500 times more potent than histamine on a molar basis in producing an equivalent decrement in the residual volume. The leukotriene C response was slow in onset and prolonged, reminiscent of the effects of aerosol allergen challenge in asthmatic allergic subjects.

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