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. 1982;7(3):127-9.
doi: 10.1007/BF00256400.

Autoradiographic comparison of 96Tc-pyrophosphate and 45Ca bone uptake

A Le Pape, A Guillemart

Autoradiographic comparison of 96Tc-pyrophosphate and 45Ca bone uptake

A Le Pape et al. Eur J Nucl Med. 1982.

Abstract

To compare the skeletal distribution of calcium and pyrophosphate complexes, autoradiograms of the growing zone of 10-week-old rabbit femurs were performed. Due to its stability to chemical and enzymatic hydrolysis and to the relatively long half-life of the isotope, 96Tc-labelled pyrophosphate was used. Calcium uptake was studied with carrier free 45Ca. For both tracers, the blood supply plays a significant role by delivering the radiopharmaceuticals. In a second step their partition was governed by mixing in different bone structures: calcium was incorporated inside the bone trabeculae and the mineral mass whereas labelled pyrophosphate remained in linear patterns surrounding bone spicules.

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References

    1. J Nucl Med. 1980 May;21(5):466-70 - PubMed
    1. Semin Nucl Med. 1976 Jan;6(1):3-18 - PubMed
    1. Biochimie. 1977;59(10):833-8 - PubMed
    1. J Nucl Med. 1975 Jan;16(1):33-9 - PubMed
    1. Clin Orthop Relat Res. 1975 May;(108):241-63 - PubMed