Comparative Study
doi: 10.1128/iai.35.3.1147-1150.1982.
Biological activities of toxins A and B of Clostridium difficile
- PMID: 7068215
- PMCID: PMC351167
- DOI: 10.1128/iai.35.3.1147-1150.1982
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Comparative Study
Biological activities of toxins A and B of Clostridium difficile
Infect Immun.
1982 Mar.
Abstract
Examination of the biological activities of the two known toxins of Clostridium difficile revealed that one of the toxins (toxin A) elicited a hemorrhagic fluid response in rabbit intestinal loops and a positive fluid response in infant mice. The other toxin (toxin B) did not produce a significant fluid response in either model, although the toxin was more lethal in infant mice. Both toxins elicited erythematous and hemorrhagic skin reactions and increased vascular permeability in rabbit skin.
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