Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1982 Apr;45(4):588-97.
doi: 10.1038/bjc.1982.96.

Spontaneously metastasizing variants derived from MNU-induced rat mammary tumour

J C Williams, B A Gusterson, R C Coombes
Free PMC article

Spontaneously metastasizing variants derived from MNU-induced rat mammary tumour

J C Williams et al. Br J Cancer. 1982 Apr.
Free PMC article

Abstract

N-methyl-N-nitrosourea (MNU) given i.v. to female rats of inbred strains induces mammary adenocarcinomas which are hormone-sensitive but do not spontaneously metastasize (Williams et al., 1981). Tissue culture and selection techniques have been used to derive metastasizing tumours from a mammary tumour induced with MNU in F344/N rats. Histologically, primary tumours and metastases in the lung and lymph nodes were similar. These systems may constitute useful models for the study of breast-cancer metastasis.

PubMed Disclaimer

References

    1. Nat New Biol. 1973 Apr 4;242(118):148-9 - PubMed
    1. J Natl Cancer Inst. 1976 Apr;56(4):797-802 - PubMed
    1. Science. 1977 Aug 26;197(4306):893-5 - PubMed
    1. Cancer Res. 1978 Sep;38(9):2962-7 - PubMed
    1. Cancer Res. 1978 Oct;38(10):3349-51 - PubMed