DNA damage in liver, kidney, bone marrow, and spleen of rats and mice treated with commercial and purified aniline as determined by alkaline elution assay and sister chromatid exchange induction
- PMID: 7074610
Item in Clipboard
DNA damage in liver, kidney, bone marrow, and spleen of rats and mice treated with commercial and purified aniline as determined by alkaline elution assay and sister chromatid exchange induction
Cancer Res.
1982 Jun.
Abstract
Aniline of unknown purity has been reported to induce spleen hemangiosarcoma in rats. Aniline has been found to be negative in terms of mutagenicity in both bacteria and yeasts. We have found that both commercial (already rather pure) and repurified aniline are clearly positive to a similar extent in inducing DNA damage in vivo in liver and kidney of rats. Both the commercial and repurified product are also clearly positive in induction of sister chromatid exchanges in vivo in male Swiss mice bone marrow cells. Liver, kidney, and bone marrow DNA damage was absent in male Swiss mice.
Similar articles
-
DNA damage induced by auramine O in liver, kidney, and bone marrow of rats and mice, and in a human cell line (alkaline elution assay and SCE induction).J Toxicol Environ Health. 1982 May-Jun;9(5-6):941-52. doi: 10.1080/15287398209530216. J Toxicol Environ Health. 1982. PMID: 7120520
-
Quantitative correlation between carcinogenicity and sister chromatid exchange induction in vivo for a group of 11 N-nitroso derivatives.J Toxicol Environ Health. 1983 Mar;11(3):337-46. doi: 10.1080/15287398309530347. J Toxicol Environ Health. 1983. PMID: 6842616
-
Inability of methapyrilene to induce sister chromatid exchanges in vitro and in vivo.Cancer Res. 1982 Nov;42(11):4614-8. Cancer Res. 1982. PMID: 7127299
-
[Aniline modification of the mutagenic activity of cyclophosphamide in a chronic experiment on mice].Gig Sanit. 1983 Aug;(8):16-8. Gig Sanit. 1983. PMID: 6354849 Review. Russian. No abstract available.
-
Proflavine, proflavine dihydrochloride, proflavine hemisulphate and proflavine monohydrochloride.IARC Monogr Eval Carcinog Risk Chem Hum. 1980;24:195-209. IARC Monogr Eval Carcinog Risk Chem Hum. 1980. PMID: 7009393 Review. No abstract available.
Cited by
-
A Novel Mast Cell Stabilizer JM25-1 Rehabilitates Impaired Gut Barrier by Targeting the Corticotropin-Releasing Hormone Receptors.Pharmaceuticals (Basel). 2022 Dec 29;16(1):47. doi: 10.3390/ph16010047. Pharmaceuticals (Basel). 2022. PMID: 36678544 Free PMC article.
-
Studies on DNA damage: discordant responses of rate of DNA disentanglement (viscosimetrically evaluated) and alkaline elution rate, obtained for several compounds. Possible explanations of the discrepancies.Cell Biophys. 1983 Dec;5(4):285-300. doi: 10.1007/BF02788627. Cell Biophys. 1983. PMID: 6202414
-
In vivo and in vitro investigations on biological effects of aromatic bis-(2-chloroethyl)amino-bisphosphonic acids, new agents proposed for chemotherapy of bone tumors: cytostatic activity in rat osteosarcoma; toxicity and genotoxicity in liver and bone marrow; mutagenicity in S. typhimurium.Invest New Drugs. 1988 Jun;6(2):67-78. doi: 10.1007/BF00195363. Invest New Drugs. 1988. PMID: 3049432
-
Toxicity of 4-chloroaniline in early life-stages of zebrafish (Brachydanio rerio): I. cytopathology of liver and kidney after microinjection.Arch Environ Contam Toxicol. 1996 Mar;30(3):390-402. doi: 10.1007/BF00212299. Arch Environ Contam Toxicol. 1996. PMID: 8854970