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Case Reports
. 1982 May;65(5):1025-9.
doi: 10.1161/01.cir.65.5.1025.

The potentiation of warfarin anticoagulation by amiodarone

A Hamer, T Peter, W J Mandel, M M Scheinman, D Weiss
Case Reports

The potentiation of warfarin anticoagulation by amiodarone

A Hamer et al. Circulation. 1982 May.

Abstract

The potentiation of the anticoagulant effect of sodium warfarin by amiodarone is reported in 10 patients. Amiodarone appears to augment the depression of vitamin K-dependent coagulation factors caused by warfarin by an uncertain mechanism, and may lead to serious bleeding. The maintenance dose of warfarin should be halved when amiodarone and warfarin are prescribed together.

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