Identification of a new phencyclidine analog, 1-(1-phenylcyclohexyl)-4-methylpiperidine, as a drug of abuse

Abstract

A previously unreported phencyclidine (PCP) analog. 1-(1-phenylcyclohexyl)-4-methylpiperidine (I) in which the piperidine ring has been substituted with 4-methylpiperidine, has been observed to be an abused drug in Virginia. The I was obtained coated over parsley in an approximate concentration of 1.7% (w/w). I . HCl was isolated, purified, and compared to authentic I . HCl (sample obtained from DEA and synthesized in the laboratory) using melting point, IR, 1H-NMR, GC and GC/MS. Unequivocal identification of I . HCl was based on its 13C-NMR. The intraperitoneal LD50 of I . HCl in male mice was 301.1 mumoles/kg (267.1--339.2, 95% confidence limits) and the ED50 was 43.0 mumoles/kg (37.3--54.3). The therapeutic index, LD50/ED50, for I . HCl was 7.0 and is much lower than that observed with phencyclidine, 38.0.