In vivo and in vitro o-methylation of 1-(3,4-dihydroxyphenyl)-2-(n-propyl-amino) propane - an intermediate in N-(N-propyl) amphetamine metabolism
- PMID: 7079586
Item in Clipboard
In vivo and in vitro o-methylation of 1-(3,4-dihydroxyphenyl)-2-(n-propyl-amino) propane - an intermediate in N-(N-propyl) amphetamine metabolism
Res Commun Chem Pathol Pharmacol.
1982 Apr.
Abstract
In vitro metabolism of 1-(3,4-dihydroxyphenyl)-2-(n-propylamino)-propane (Id) by rat liver cytosol in the presence of S-adenosyl-L-methyl-methionine produced almost quantitatively the corresponding 3-methoxy metabolite. 1-(4-Hydroxy-3-methoxyphenyl)-2-(n-propylamino) propane was also recovered from the urine of rats dosed with the catecholamine (Id).
Similar articles
-
In vivo phenolic metabolites of N-alkylamphetamines in the rat. Evidence in favor of catechol formation.Drug Metab Dispos. 1976 May-Jun;4(3):256-61. Drug Metab Dispos. 1976. PMID: 6230
-
In vitro metabolism of the new cardiotonic agent denopamine (TA-064) by rat and rabbit liver preparations. Oxidation, methylation, and glucuronidation.Drug Metab Dispos. 1985 Mar-Apr;13(2):246-54. Drug Metab Dispos. 1985. PMID: 2859176
-
Biotransformation of aliphatic formamides: metabolites of (+-)-N-methyl-N-(1-methyl-3,3-diphenylpropyl) formamide in rats.Biomed Environ Mass Spectrom. 1989 Sep;18(9):690-701. doi: 10.1002/bms.1200180908. Biomed Environ Mass Spectrom. 1989. PMID: 2790257
-
[Methylation processes in catecholamine metabolism].Vopr Med Khim. 1965 Mar-Apr;11(2):3-16. Vopr Med Khim. 1965. PMID: 5328489 Review. Russian. No abstract available.
-
Methylation reactions in the formation and metabolism of catecholamines and other biogenic amines.Pharmacol Rev. 1966 Mar;18(1):95-113. Pharmacol Rev. 1966. PMID: 5323771 Review. No abstract available.