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. 1978 Sep;14(3):465-9.
doi: 10.1128/AAC.14.3.465.

Combined activity of minocycline and amphotericin B in vitro against medically important yeasts

M A Lew, K M Beckett, M J Levin

Combined activity of minocycline and amphotericin B in vitro against medically important yeasts

M A Lew et al. Antimicrob Agents Chemother. 1978 Sep.

Abstract

The capacity of minocycline to enhance the activity of amphotericin B against Candida albicans, Torulopsis glabrata, Cryptococcus neoformans, and non-albicans Candida was examined in vitro utilizing a time-killing curve technique. Synergism was apparent at 4 h with 5 of 5 strains of C. albicans, 8 of 8 strains of C. neoformans, and 1 of 12 strains of non-albicans Candida. Synergism was apparent at 24 h with the remaining 11 strains of non-albicans Candida and all 5 strains of T. glabrata. C. neoformans was the most susceptible of the yeasts to the minocycline-amphotericin B combination; seven strains showed a 3-log or greater reduction in colony count in 4 h and all strains showed this reduction in 24 h at amphotericin B concentrations of 0.4 mug/ml or less in the presence of minocycline.

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References

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