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. 1982 Apr;90(2):169-71.
doi: 10.1111/j.1699-0463.1982.tb00100.x.

A heat-labile necrotic activity in supernatants from cultures of Legionella pneumophila

B P Berdal, O Olsvik, A A Ogaard

A heat-labile necrotic activity in supernatants from cultures of Legionella pneumophila

B P Berdal et al. Acta Pathol Microbiol Immunol Scand B. 1982 Apr.

Abstract

Crude, concentrated extra-cellular supernatants from Legionella pneumophila produced a soft-tissue necrosis, demonstrated by intraperitoneal or sub-cutaneous injections into infant mice. The reaction was rapid and gave a hemorrhagic tissue necrosis within minutes. Being heat-labile, this tissue reaction is different from those of a heat-stable cytotoxin and a heat-stable hemolysin previously described.

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