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. 1982 Apr;12(1-2):180-2.
doi: 10.1007/BF01965139.

Influence of nonsteroidal anti-inflammatory compounds on healing of chronic gastric ulcers in rats

I Szelenyi, H Engler, P Herzog, S Postius, H Vergin, K H Holtermüller

Influence of nonsteroidal anti-inflammatory compounds on healing of chronic gastric ulcers in rats

I Szelenyi et al. Agents Actions. 1982 Apr.

Abstract

Pre-treatment with NOSAC led to an increase of ulcer index in a dose-dependent manner indicating the aggravation of gastric lesions under the influence of NOSAC. The severity of mucosal lesions was diminished by lengthening the time between the last day of pre-treatment with NOSAC and the day on which ulcers were induced. When NOSAC were administered after the induction of gastric ulcers, the healing of the latter was significantly delayed.

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