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. 1982 May;34(3):459-68.

Direct chromosomal analysis of human spermatozoa: preliminary results from 18 normal men

R H Martin, C C Lin, W Balkan, K Burns

Direct chromosomal analysis of human spermatozoa: preliminary results from 18 normal men

R H Martin et al. Am J Hum Genet. 1982 May.

Abstract

Chromosomal analysis of 240 spermatozoa from 18 normal men was performed using in vitro fertilization of zona-free golden hamster eggs. The frequency of chromosome abnormalities in this population was 9.2% (22/240). Of the abnormal complements, 18 were aneuploid (13 hyperploid and five hypoploid) and four had a chromosome break. The sex ratio of Y-bearing to X-bearing sperm was .68. The frequency and type of sperm chromosome abnormalities is compared with those seen in spontaneous abortions.

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