Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1982 May;125(5):610-1.
doi: 10.1164/arrd.1982.125.5.610.

Amphotericin B in liposomes: a novel therapy for histoplasmosis

R L Taylor, D M Williams, P C Craven, J R Graybill, D J Drutz, W E Magee

Amphotericin B in liposomes: a novel therapy for histoplasmosis

R L Taylor et al. Am Rev Respir Dis. 1982 May.

Abstract

Incorporation of amphotericin B into liposomes significantly altered its toxicity, tissue distribution, and efficacy. Compared with intravenously administered amphotericin B-desoxycholate, liposome-amphotericin B showed a reduced acute toxicity and a maximal tolerable dose 9 times greater than amphotericin B-desoxycholate. Liposome-amphotericin B also produced higher tissue and lower serum concentrations than amphotericin B-desoxycholate, and was significantly more effective in prolonging survival of mice infected with Histoplasma capsulatum.

PubMed Disclaimer

Publication types

LinkOut - more resources