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. 1982 Jan;21(1):44-50.
doi: 10.1128/AAC.21.1.44.

Uptake, distribution, and anabolism of acyclovir in herpes simplex virus-infected mice

K K Biron, J E Noblin, P de Miranda, G B Elion

Uptake, distribution, and anabolism of acyclovir in herpes simplex virus-infected mice

K K Biron et al. Antimicrob Agents Chemother. 1982 Jan.

Abstract

The uptake, distribution, and anabolism of the nucleoside analog 9-(2-hydroxyethoxymethyl) guanine (acyclovir) were compared in herpes simplex virus-infected and uninfected mice. Analyses of tissue distribution and the concentration of acyclovir after either a single dose or multiple doses failed to reveal significant differences between drug levels in infected and uninfected animals. Extracts of tissues from [8-14C] acyclovir-treated animals were examined by high-performance liquid chromatography to detect the presence of any phosphorylated forms of the drug. The sensitivity of this method did not allow a reproducible demonstration of acyclovir anabolism in herpes simplex virus-infected tissues owing to the low numbers of infected cells per organ.

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