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. 1982 Jan 15;202(1):275-8.
doi: 10.1042/bj2020275.

Lymphocytes induce resorption of cartilage by producing catabolin

J Saklatvala, S J Sarsfield

Lymphocytes induce resorption of cartilage by producing catabolin

J Saklatvala et al. Biochem J. .

Abstract

Mononuclear cells from pig blood, when cultured in the presence of lectins (concanavalin A or phytohaemagglutinin), release a factor that induces resorption of proteoglycan in explants of live bovine nasal cartilage. The factor had mol.wt. 20000 and pI 4.6-5.0, and was indistinguishable from the cartilage-catabolic protein catabolin isolated from culture medium of explants of pig synovial tissue. Since much of the catabolin from the mononuclear cells arose from the non-adherent population (98% lymphocytes) it was concluded that lymphocytes (and possibly monocytes) make catabolin.

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