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Case Reports
. 1982 Jun;106(6):687-95.
doi: 10.1111/j.1365-2133.1982.tb11684.x.

Pharmacological modulation of neutrophil phagocytic function in a patient with recurrent sepsis, pyoderma gangrenosum and impaired phagocytosis

C B Bentley-Phillips, R C Cooper, A F Hallett
Case Reports

Pharmacological modulation of neutrophil phagocytic function in a patient with recurrent sepsis, pyoderma gangrenosum and impaired phagocytosis

C B Bentley-Phillips et al. Br J Dermatol. 1982 Jun.

Abstract

A 50-year-old man with recurrent life-threatening sepsis and a cutaneous condition resembling pyoderma gangrenosum, was found to have a defect of neutrophil phagocytic function. Phagocytosis could be enhanced by corticosteroids, both in vitro in a dose-dependent manner, and in vivo, when it was accompanied by rapid clinical improvement. Studies with steroid hormones and immuno-stimulatory drugs are described.

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