Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1982;7(2-3):147-50.
doi: 10.1007/BF00254537.

Pharmacokinetics of Teniposide (VM26) and etoposide (VP16-213) in children with cancer

W E Evans, J A Sinkule, W R Crom, L Dow, A T Look, G Rivera

Pharmacokinetics of Teniposide (VM26) and etoposide (VP16-213) in children with cancer

W E Evans et al. Cancer Chemother Pharmacol. 1982.

Abstract

The clinical pharmacokinetics of VM26 and VP16-213 were assessed in 15 children (median age 10 years) with acute leukemia, using a new high-performance liquid chromatography-electrochemical assay. Pharmacokinetic parameters were calculated by both model-dependent and compartment model-independent methods. These studies demonstrated substantial differences in the central volumes of distribution (VDc), steady-state volumes of distribution (VDss) and systemic clearances (Cls) of VM26 and VP16-213; with the VDc, VDss, and Cls all being smaller for VM26, Systemic clearances determined by model-independent methods were 5.2 +/- 1.0 ml/min/m2 (mean +/- SD) for VM26 and 17.8 +/- 11.2 ml/min/m2 for VP16-213. The major metabolites. detected in serum and urine were the hydroxy acids. Low levels of the picro-lactone isomers were detected in some patients while the aglycones were not detected in the serum or urine of any patients.

PubMed Disclaimer

References

    1. Adv Intern Med. 1980;25:427-52 - PubMed
    1. Eur J Cancer. 1975 Oct;11(10):697-707 - PubMed
    1. J Chromatogr. 1980 May 9;182(2):211-20 - PubMed
    1. J Med Chem. 1977 May;20(5):635-44 - PubMed
    1. J Med Chem. 1979 Mar;22(3):215-21 - PubMed

Publication types