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. 1982 Jul;28(7):1482-4.

Verapamil and calcium-stimulated enzyme efflux from skeletal muscle

R Anand, A E Emery
  • PMID: 7083559

Verapamil and calcium-stimulated enzyme efflux from skeletal muscle

R Anand et al. Clin Chem. 1982 Jul.

Abstract

An early and significant biochemical abnormality in Duchenne's muscular dystrophy is an increase in intracellular calcium. We have found that the "calcium-blocker" drug verapamil inhibits calcium-stimulated efflux of creatine kinase (EC 2.7.3.2) and lactate dehydrogenase (EC 1.1.1.27) in vitro from normal human skeletal muscle at therapeutic concentrations. Such a calcium blocker might therefore be useful in the treatment of Duchenne's muscular dystrophy.

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