Verapamil and calcium-stimulated enzyme efflux from skeletal muscle
- PMID: 7083559
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Verapamil and calcium-stimulated enzyme efflux from skeletal muscle
Clin Chem.
1982 Jul.
Abstract
An early and significant biochemical abnormality in Duchenne's muscular dystrophy is an increase in intracellular calcium. We have found that the "calcium-blocker" drug verapamil inhibits calcium-stimulated efflux of creatine kinase (EC 2.7.3.2) and lactate dehydrogenase (EC 1.1.1.27) in vitro from normal human skeletal muscle at therapeutic concentrations. Such a calcium blocker might therefore be useful in the treatment of Duchenne's muscular dystrophy.
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