doi: 10.1007/BF01952651.
Studies on the in vitro binding of D-penicillamine to cholestyramine
- PMID: 7084416
- DOI: 10.1007/BF01952651
Item in Clipboard
Studies on the in vitro binding of D-penicillamine to cholestyramine
Experientia.
.
Abstract
Adsorption of D-penicillamine to cholestyramine depends on the amount of the resin, the pH and the presence of other compounds such as bile salts. In the usual drug to resin ratio (150 mg D-penicillamine and 4-8 g cholestyramine per single dose) the percentage of D-penicillamine adsorbed to cholestyramine was about 10% of the applied dose; Bile salts (10 mmoles/l) inhibited this small adsorption by 87%.
Similar articles
-
Binding of bile acids to cholestyramine at gastric pH conditions.J Pharm Sci. 1975 Nov;64(11):1887-9. doi: 10.1002/jps.2600641133. J Pharm Sci. 1975. PMID: 486
-
Adsorption of bile acids by sucralfate, antacids, and cholestyramine in vitro.Clin Ther. 1987;9(6):615-21. Clin Ther. 1987. PMID: 3440273
-
Comparison of antacids on the binding of bile salts.Arch Surg. 1984 Sep;119(9):1018-20. doi: 10.1001/archsurg.1984.01390210022006. Arch Surg. 1984. PMID: 6477113
-
Antacids and bile salts.Scand J Gastroenterol Suppl. 1982;75:16-9. Scand J Gastroenterol Suppl. 1982. PMID: 6755652 Review.
-
Dietary fiber as a binder of bile salts.Nutr Rev. 1977 Jul;35(7):183-5. doi: 10.1111/j.1753-4887.1977.tb06587.x. Nutr Rev. 1977. PMID: 331148 Review. No abstract available.
Cited by
-
Modulation of base hydroxylation by bile acids and salicylates in a model of human colonic mucosal DNA: putative implications in colonic cancer.Dig Dis Sci. 1999 Apr;44(4):761-7. doi: 10.1023/a:1026670027150. Dig Dis Sci. 1999. PMID: 10219835