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. 1982 Apr 15;38(4):482-4.
doi: 10.1007/BF01952651.

Studies on the in vitro binding of D-penicillamine to cholestyramine

H Allgayer, W Kruis, G Paumgartner

Studies on the in vitro binding of D-penicillamine to cholestyramine

H Allgayer et al. Experientia. .

Abstract

Adsorption of D-penicillamine to cholestyramine depends on the amount of the resin, the pH and the presence of other compounds such as bile salts. In the usual drug to resin ratio (150 mg D-penicillamine and 4-8 g cholestyramine per single dose) the percentage of D-penicillamine adsorbed to cholestyramine was about 10% of the applied dose; Bile salts (10 mmoles/l) inhibited this small adsorption by 87%.

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