doi: 10.1093/bja/50.9.885.
Effects of age and sex on ketamine anaesthesia in the rat
- PMID: 708555
- DOI: 10.1093/bja/50.9.885
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Effects of age and sex on ketamine anaesthesia in the rat
Br J Anaesth.
1978 Sep.
Free article
Abstract
Intraperitoneal injections of ketamine 75 mg kg-1 in rats of both sexes (age 1--16 weeks) revealed a significant relationship between increased age and decreased duration of sleeping time for both sexes during the first 3 weeks of age. This decrease in sleeping time seemed to be associated with the increased production of the cyclohexanone oxidation metabolite of ketamine. After 3 weeks of age there was a greater sleeping time in the female rat than the male and this seemed to be associated with a greater ability of the male to produce the cyclohexanone oxidation metabolite.
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