Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1982 Jun;35(6):661-6.
doi: 10.1136/jcp.35.6.661.

Antithrombin III and fibrinogen degradation product (fragment E) in diabetic nephropathy

V Chan, C K Yeung, T K Chan

Antithrombin III and fibrinogen degradation product (fragment E) in diabetic nephropathy

V Chan et al. J Clin Pathol. 1982 Jun.

Abstract

Plasma antithrombin III (AtIII), serum fragment E (FgE) and urine AtIII and FgE were measured in 25 diabetic patients with proteinuria above 1 g per day and compared to that in 25 patients with non-diabetic nephropathy, matched for the degree of proteinuria. Plasma AtIII concentrations were normal in both groups but FgE concentrations were increased. The level of plasma AtIII was directly related to HbA1 concentrations in the diabetics. For the same degree of proteinuria, the diabetic patients lost more AtIII and FgE in the urine. Urine AtIII was found to be mostly bound to activated procoagulants. Both urine AtIII and urine FgE correlated inversely with creatinine clearance. It was concluded that intraglomerular thrombosis probably contributes to the deteriorating renal function in diabetic nephropathy and is reflected in the concentrations of urine AtIII and FgE.

PubMed Disclaimer

References

    1. Am J Med. 1969 May;46(5):774-86 - PubMed
    1. Br Med J. 1971 Aug;3(5772):447-51 - PubMed
    1. Diabetologia. 1972 Apr;8(2):84-92 - PubMed
    1. J Clin Pathol. 1972 Aug;25(8):657-67 - PubMed
    1. Q J Med. 1972 Oct;41(164):437-56 - PubMed

Substances