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. 1982 Jul 16;217(4556):261-3.
doi: 10.1126/science.7089564.

An enzymatic system for removing heparin in extracorporeal therapy

R Langer, R J Linhardt, S Hoffberg, A K Larsen, C L Cooney, D Tapper, M Klein

An enzymatic system for removing heparin in extracorporeal therapy

R Langer et al. Science. .

Abstract

The need to fully heparinize patients undergoing extracorporeal therapy often leads to hemorrhagic complications. To enable heparinization of only the extracorporeal circuit, a blood filter containing immobilized heparinase was developed. This filter degraded 99 percent of heparin's anticoagulant activity within minutes in both canine and human blood.

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