doi: 10.3109/00498258209046787.
Hepatic microsomal metabolism of 1,3-butadiene
- PMID: 7090423
- DOI: 10.3109/00498258209046787
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Hepatic microsomal metabolism of 1,3-butadiene
Xenobiotica.
1982 Feb.
Abstract
1. In rat liver microsomes, 1,3-butadiene was metabolized to butadiene monoxide, which was subsequently transformed into 3-butene-1,2-diol by microsomal epoxide hydrolase. 2. In the metabolism of butadiene oxide in microsomes, four metabolites were detected, namely two stereoisomers of DL-diepoxybutane, and two stereoisomers of 3,4-epoxy-1,2-butanediol. No meso-diepoxybutane was detected.
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