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Case Reports
. 1982 Jul;66(7):422-31.
doi: 10.1136/bjo.66.7.422.

Tapetoretinal degeneration in the cerebro-hepato-renal (Zellweger's) syndrome

A Garner, A R Fielder, R Primavesi, A Stevens
Case Reports

Tapetoretinal degeneration in the cerebro-hepato-renal (Zellweger's) syndrome

A Garner et al. Br J Ophthalmol. 1982 Jul.

Abstract

Electrophysiological and histopathological study of a baby suffering from Zellweger's syndrome and presenting progressive retinal dysfunction showed this to be related to degenerative changes in the photoreceptor cells and pigment epithelium and to defective myelination of the optic nerve. Disturbances of bile acid and lysine metabolism were also demonstrated, lending support to the concept that Zellweger's syndrome is attributable to a widespread inadequacy of intracellular oxidative function.

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References

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