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. 1982;28(3):209-12.
doi: 10.1159/000238078.

Induced resistance in leukaemia L1210 to adriamycin and its cross-resistance to vincristine and bouvardin

M P Chitnis, S S Joshi, R P Gude, R S Menon

Induced resistance in leukaemia L1210 to adriamycin and its cross-resistance to vincristine and bouvardin

M P Chitnis et al. Chemotherapy. 1982.

Abstract

The induction of complete resistance to adriamycin in L1210 leukemia was accomplished after 10 transplant generations. The adriamycin-resistant subline showed cross-resistance to vincristine and bouvardin. It was sensitive to methotrexate; this was observed by a 50% increase in life span compared to the life span of untreated control animals.

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