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. 1978 Oct 7;119(7):733,-5, 738.

Impaired serum antibody response to inactivated influenza A and B vaccine in cancer patients

H G Stiver, B H Weinerman

Impaired serum antibody response to inactivated influenza A and B vaccine in cancer patients

H G Stiver et al. Can Med Assoc J. .

Abstract

The serum antibody response to vaccination with bivalent inactivated influenza vaccine containing A/Port Chalmers/1/73 (H3N2) and B/Hong Kong/5/72 antigens was assessed in 44 patients with cancer and in 27 healthy control subjects. A fourfold or greater increase in antibody titre after vaccination occurred in 16 of the 44 cancer patients and 25 of the 27 controls for the A antigen, and in 14 of the 44 cancer patients and 20 of the 27 controls for the B antigen. Patients with lymphoma, who tended to have hypogammaglobulinemia, responded less well than did patients with solid tumours. Among the latter the failure to show a fourfold or greater increase in antibody titre correlated with a poorer 18-month survival.

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