Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1982 May;93(2):426-31.
doi: 10.1083/jcb.93.2.426.

Differential conservation of histone 2A variants between mammals and sea urchins

R S Wu, D Nishioka, W M Bonner
Comparative Study

Differential conservation of histone 2A variants between mammals and sea urchins

R S Wu et al. J Cell Biol. 1982 May.

Abstract

The histone 2A proteins of the sea urchin Strongylocentrotus purpuratus are compared with those of the mouse. While the major H2As in these two organisms do not comigrate on two-dimensional gels, the sea urchin contains a protein that comigrates with the minor histone 2A variant H2A.Z from mammals. H2A.Z is of particular interest because its sequence homology with other H2As is quite low, and it is not phosphorylated as are other H2As. A comparison of the tryptic peptide patterns of several H2As from sea urchin blastulae and mouse L1210 cells show that, while the patterns of the H2A.Zs differ greatly from the patterns of the other H2As, the patterns of the mouse and sea urchin H2A.Zs are very similar. Since the H2A.Zs have only one or two peptides in common with the other H2As, the conservation of their sequence indicates that H2A.Zs have evolved under somewhat different selective pressures from other H2As. Unlike all the other sea urchin H2As whose syntheses either turn on or off during early development, H2A.Z seems to be synthesized continuously throughout this period.U

PubMed Disclaimer

References

    1. Exp Cell Res. 1970 Jul;61(1):69-70 - PubMed
    1. J Biol Chem. 1972 Oct 10;247(19):6018-23 - PubMed
    1. Eur J Biochem. 1974 Feb 1;41(3):563-76 - PubMed
    1. Eur J Biochem. 1974 Jul 1;46(1):83-8 - PubMed
    1. Dev Biol. 1974 Dec;41(2):352-70 - PubMed

Publication types