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Case Reports
. 1982 Mar-Apr;6(2):82-4.
doi: 10.1093/jat/6.2.82.

Toxicological findings in amoxapine overdose

P Sedgwick, V R Spiehler, D R Lowe
Case Reports

Toxicological findings in amoxapine overdose

P Sedgwick et al. J Anal Toxicol. 1982 Mar-Apr.

Abstract

Tissue concentrations of amoxapine, a new antidepressant with antipsychotic properties, were determined in two cases in which amoxapine was taken in overdose. Two extractions and GLC procedures, UV spectra, and TLC properties of amoxapine are described. The concentrations of amoxapine are described. The concentrations of amoxapine in brain tissue (52 micrograms/g and 53.2 micrograms/g) were about equal to concentrations found in liver (77 micrograms/g and 50 micrograms/g) and higher than blood concentrations (6 micrograms/mL and 1.5 micrograms/mL). The two metabolites of amoxapine, 8-hydroxyamoxapine and 7-hydroxyamoxapine, were not detected by TLC or GLC.

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