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. 1982 Mar;7(2):139-44.
doi: 10.1016/0160-5402(82)90026-2.

A practical method for monitoring drug excretion and enterohepatic circulation in the rat

F L Tse, F Ballard, J M Jaffe

A practical method for monitoring drug excretion and enterohepatic circulation in the rat

F L Tse et al. J Pharmacol Methods. 1982 Mar.

Abstract

An improved experimental design for studying the enterohepatic circulation of drugs in a pair of bile duct-duodenum cannula-linked rats is described. By housing the rats in individual metabolism cages and using a peristaltic pump to immediately deliver bile secreted by the donor directly into the duodenum of the recipient, the method permits a realistic approximation of biliary excretion and reabsorption in intact animals for periods up to 96 hours.

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