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. 1982 Aug 5;298(5874):534-8.
doi: 10.1038/298534a0.

Formation of transmembrane tubules by spontaneous polymerization of the hydrophilic complement protein C9

J Tschopp, H J Müller-Eberhard, E R Podack

Formation of transmembrane tubules by spontaneous polymerization of the hydrophilic complement protein C9

J Tschopp et al. Nature. .

Abstract

The ninth component of complement C9 can undergo circular polymerization in the fluid phase and on lipid membranes. The concomitant hydrophilic-amphiphilic transition is the result of a conformational reorganization of C9 and allows insertion of poly C9 into membranes in the form of a transmembrane protein channel. The ultrastructure of poly C9 resembles that of membrane lesions caused by complement.

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